We develop new dyes and use existing ones to construct advanced molecular probes for quantitative imaging of physiological processes in vivo. Our research can be divided into three interconnected areas:
Over the years, one of our central research topics has been optical imaging of oxygen by phosphorescence quenching, including chemistry of imaging probes, phosphorescence lifetime imaging instrumentation, image reconstruction methods and various applications of phosphorescence.
Our research is funded mainly by the US National Institutes of Health (NIBIB, NINDS, NCI).
University of Pennsylvania
Department of Biochemistry and Biophysics, Perelman School of Medicine
Department of Chemistry, School of Arts and Sciences
Philadelphia, PA 19104
The Vinogradov Group website